The season opener was a matchup between the top two preseason northern Kentucky teams, Highlands (ranked first) and Ryle (ranked second). Highlands dominated the game, leading 28-0 at halftime en route to a 49-21 victory at Ryle. The 'Birds were led by RB Josh Conner, who racked up 227 yards and five TDs on 19 carries. Highlands outgained Ryle 472 yards to 272 yards in the game. Highlands QB Clay Cecil ran for 46 yards (and one TD) and was 6-9 passing for 96 yards. Highlands' 2007 varsity record to-date: 1-0.
Also, Highlands junior varsity (JV) defeated Ryle 21-0 to begin the JV season 1-0.